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Background Precision medicine tailors an individual’s healthcare to their genetics, environment and behaviour. This has been driven by rapid advances in genomics, where an individual’s entire genetic code can now be sequenced. General practitioners (GPs) are increasingly involved in genomics throughout the lifespan, including performing prenatal screening during pregnancy, requesting reproductive genetic carrier screening and arranging genetic referrals for cancer and other conditions. Patients are relying on their GPs to appropriately counsel, test, refer and manage genetic conditions, and provide genomic healthcare. Objective This article provides an overview of the GP’s expanding role in genomic medicine, some tools to assist GPs to navigate this landscape, and barriers to genomic uptake. Discussion GPs are integral to supporting patients and families in the genomics and precision medicine era. Resources specifically aimed at, and codesigned with, GPs are required to enable broader and equitable access for the benefit of all Australians. Now more than ever, general practitioners (GPs) have a key role in genomic medicine. With their existing expertise in risk screening and family- and patient-centered care, GPs are already arranging genetic testing of chromosomes and single genes and arranging referrals for genomic testing (incorporating an individual’s entire genetic makeup). Genomic medicine is increasingly relevant for GPs caring for their patients across their lifespans, covering pregnancy-related screening, cancer, cardiology, neurology and many other areas of medicine.1–4 Recent rapid advances have led to cheaper, more accurate and faster genomic testing and screening options and the emergence of advanced therapies for conditions such as cancer, neuromuscular disease and genetic blindness.5 This has paved the way for precision medicine – defined as a tailored healthcare approach incorporating relevant genetic, environmental and behavioural information into a person’s care. This offers a major new frontier in medicine and much promise for disease prevention and cure.6 For example, genomic-based targeted treatments for cancer; tailored medication prescribing guided by pharmacogenomics;7 polygenic scores supporting stratification of the population by disease risk for common conditions such as heart disease and cancer;8 and population-based genetic screening,9 reducing unnecessary interventions and improving healthcare at scale.5,10 Precision medicine is listed as a future-focused healthcare priority by the Commonwealth in ‘Australia’s Primary Health Care 10 Year Plan 2022–2032’.11 The PRECISE (Practitioner Readiness, Education, Capabilities with Implementation Science Evaluation) genomics project is currently embarking on improving genomic resources for Australian GPs to support their provision of genetic healthcare. This paper will provide an overview of: - GPs’ expanding role in clinical genomics - tools and resources that can support GPs to navigate genomics - barriers to GP uptake of genomics.